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Were the aims/objectives of the study clear?
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Was the study design appropriate for the stated aim(s)?
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Was the sample size justified?
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Was the target/reference population clearly defined?
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Was the sample frame taken from an appropriate population base so that it closely represented the target/reference population?
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Was the selection process likely to select subjects/participants that were representative of the target/reference population?
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Were measures undertaken to address and categorize non-responders?
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Were the risk factor and outcome variables measured appropriate to the aims of the study?
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Were the risk factor and outcome variables measured correctly using instruments/measurements that had been trialled, piloted or published previously?
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Is it clear what was used to determine statistical significance and/or precision estimates?
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